Meeflon ® 500 (Micronized purified flavonoid fraction) Tablets, Use in chronic venous insufficiency, venous ulcers and haemorrhoids.

Meeflon ® 500 (Micronized purified flavonoid fraction) Tablets, An oral phlebotropic drug consisting of 90% micronised diosmin and 10% flavonoids expressed as hesperidin, improves venous tone and lymphatic drainage, and reduces capillary hyperpermeability by protecting the microcirculation from inflammatory processes. Use in chronic venous insufficiency, venous ulcers and haemorrhoids.

Meeflon® 500 (Micronized purified flavonoid fraction) Tablets
is a micronized purified flavonoid fraction containing 90% diosmin and
10% other flavonoids expressed as hesperidin.

Meeflon® 500 - This pill is a venotonic (it increases venous tone) and a vasculoprotector (it increases resistance in small blood vessels).
It is recommended for treating venous circulation disorders (swollen legs, pain, restless legs) and for treating acute hemorrhoidal attack.
Dosage:
For venous insufficiency, the dosage is 2 tablets daily. For acute hemorrhoidal attack, the dosage is 6 tablets daily
for 4 days, followed by 4 tablets daily over the next 3 days.
Side effect: Possible side effects include routine gastric disorders and neurovegetative disorders.

Micronised purified flavonoid fraction (MPFF) [Meeflon 500 mg], an oral phlebotropic drug consisting of 90% micronised diosmin and 10% flavonoids expressed as hesperidin, improves venous tone and lymphatic drainage, and reduces capillary hyperpermeability by protecting the microcirculation from inflammatory processes. The absorption of diosmin is improved by its micronisation to particles with a diameter <2 microm. Compared with placebo, MPFF 500 mg twice daily significantly decreased ankle or calf circumference, and improved many symptoms of chronic venous insufficiency (CVI) and plethysmographic parameters in two randomised, double-blind, 2-month studies. Improvement in symptoms was parallelled by an improvement in health-related quality of life in a nonblind, 6-month trial. Significantly more venous leg ulcers </=10 cm in diameter completely healed with MPFF 500 mg twice daily plus standard management (compression and local treatment) for 2-6 months than with standard management alone or with placebo in a nonblind and a double-blind trial. The addition of MPFF to standard management was cost effective in a retrospective pharmacoeconomic analysis of the 6-month trial. Compared with placebo, the duration and/or intensity of individual symptoms of grade 1 or 2 acute internal haemorrhoids improved significantly with 3 tablets of MPFF 500 mg twice daily for 4 days then 2 tablets of MPFF 500 mg twice daily for 3 days. Two tablets of MPFF 500 mg daily for 60 or 83 days reduced the frequency, duration and/or severity of acute haemorrhoidal symptoms and improved the overall signs and symptoms of chronic (recurrent) haemorrhoids compared with placebo. Compared with a control group, MPFF significantly reduced the risk of secondary bleeding after elective haemorrhoidectomy. In clinical trials, MPFF had a tolerability profile similar to that of placebo; the most frequently reported adverse events were gastrointestinal and autonomic in nature. In conclusion, MPFF is a well established and well tolerated treatment option in patients with CVI, venous ulcers, or acute or chronic internal haemorrhoids. MPFF is indicated as a first-line treatment of oedema and the symptoms of CVI in patients in any stage of the disease. In more advanced disease stages, MPFF may be used in conjunction with sclerotherapy, surgery and/or compression therapy, or as an alternative treatment when surgery is not indicated or is unfeasible. The healing of venous ulcers </=10 cm in diameter is accelerated by the addition of MPFF to standard venous ulcer management. MPFF may reduce the frequency, duration and/or intensity of symptoms of grade 1 or 2 acute internal haemorrhoids, and also the severity of the signs and symptoms of chronic haemorrhoids.

Effect of oral micronized purified flavonoid fraction treatment on leukocyte adhesion molecule expression in patients with chronic venous disease: A pilot study******

Abstract

Purpose : The purpose of this study was to determine the effects of a micronized purified flavonoid fraction treatment on surface expression of leukocyte adhesion molecules in chronic venous disease (CVD). Methods : Twenty patients with chronic venous disease were assessed with the use of clinical and Duplex scanning criteria. Consenting patients were treated for 60 days with a micronized purified flavonoid fraction treatment (500 mg twice daily). Blood was collected from a foot vein immediately before the start of treatment and within 1 week after the treatment was stopped. Neutrophil and monocyte surface adhesion molecule expression was determined by flow cytometry using the monoclonal antibodies to CD11b and CD62L. Results : Neutrophil CD11b (248:212), monocyte CD11B (204:190), neutrophil CD62L (130:97 [P =.002]), and monocyte CD62L (170:121 [P =.03]) were determined, respectively, before and after treatment. All values are arbitrary units and represent median values. Conclusion : Micronized purified flavonoid fraction treatment for 60 days seems to decrease the surface expression of CD62L by neutrophils and by monocytes. The clinical significance of this finding needs to be explored further. It is feasible to use changes in the levels of these molecules as a marker for response to therapy in chronic venous disease. (J Vasc Surg 2000;31:456-61.)

Address Russian State Medical University 

1, Ostrovityanova Street

  City/town Moscow

  Zip/Postcode 117997

  Country Russian Federation

Sponsor Institut de Recherches Internationales Servier (France)

  Address 50 rue Carnot

  City/town Suresnes

  Zip/Postcode 92284

  Country France

Micronized Purified Flavonoid Fraction and the Treatment of Chronic Venous Insuf.

Introduction:

The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There is a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia/reperfusion (I/R) show that micronized purified flavonoid fraction (MPFF) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is some evidence that MPFF promotes venous leg ulcer healing.

Keywords:

ambulatory venous hypertension, flavonoid treatment, microcirculation, neutrophils, varicose ulceration, varicose veins. 

Daflon 500 (Rutaceae) - 500mg (10 Tablets)

Daflon 500 (Rutaceae) - 500mg (10 Tablets)

Brand Name: Meeflon 500

Generic Name: Rutaceae

Form: Tablets

Manufacturer: Taj Pharmaceuticals Ltd.

What is Meeflon 500?

Meeflon 500 is a unique micronized purified flavonoid fraction, extracted from citrus fruit plants. It is mainly prescribed for patients who cannot get the necessary amounts in their regular diets. It is generally used to treat conditions caused by chronic venous disease (CVD) like swollen legs, nocturnal cramps and varicose veins. Some people may also use it to treat acute hemorrhoidal attacks and prevents further bleeding episodes.

How is Meeflon 500 used? 

Meeflon 500 is usually taken orally twice daily, once in the afternoon and once in the evening. The tablets should be taken with some food along with some fluids. Contact a doctor for the correct dosage and length of treatment as it will depend on the condition being treated and the patient�s response to the therapy. The tablet should be swallowed whole and not crushed, chewed or cut.

Adverse effects

Meeflon 500 may cause unwanted side effects such as:

Difficulty breathing or swallowing

Unusual taste in mouth

Headaches

Upset stomach

Contact a doctor immediately should side effects persist or worsen.

Warnings

Immediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.

Daflon 500 is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.

The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.

Details

SKU 345345434444

Our price: $5.11

Use in pregnancy: Experimental studies in animal have not demonstrated any teratogenic effect and no harmful effects have been reported in human to date.
Use in lactation: In absence of data concerning the diffusion into breast milk, breast-feeding is not recommended during treatment.
• In hemorrhoidal disease:
For acute disease: 6 tablets daily for 4 days, then 4 tablets daily for 3 days
For chronic disease: 2 tablets daily
• In chronic venous disease: 2 tablets daily
• For Lymphedema : 2 tablets daily

Meeflon Tablet: Each film coated tablet contains micronized purified flavonoid fraction 500 mg: Diosmin BP 450 mg & Hesperidin INN 50 mg.

© 2014. Taj Pharma Ltd. All rights reserved.

TOPAMET ® (topiramate) Tablets 15/25/50/100 & 200mg, Topiramate belongs to a group of medicines called antiepileptic medicines.

TOPAMET ® (topiramate) Tablets 15/25/50/100 & 200mg, Topiramate belongs to a group of medicines called antiepileptic medicines.







TREAT EPILEPSY AND PREVENT SEIZURES,
ALSO TO PREVENT MIGRAINE ATTACKS

TOPAMET® tablets 15mg contain topiramate, an anticonvulsant used to treat epilepsy and control
seizures, also to prevent migraine attacks.

What is TOPAMET® used for?
TOPAMET ® tablets 15mg are used to treat epilepsy in adults and children to control seizures, which happen
when there is abnormal electrical activity in the brain. TOPAMET® tablets 15mg are used as monotherapy
(on its own) for adults and children (over 6) who have just been diagnosed with idiopathic epilepsy
(of unknown cause) and who have either generalised tonic-clonic seizures, seizures affecting the whole
brain (formerly known as grand mal seizures), which usually last 1-3 minutes; or partial seizures, which
affect only part of the brain but can spread to the whole brain and these are called secondarily
generalised seizures. TOPAMET® tablets 15mg are also used in addition to another medication for
controlling seizures in adults and children (over 2 years of age) in partial onset seizures, generalised
tonic-clonic seizures but who have been unable to achieve control of seizures with other medications;
also in children for treatment seizures associated with of Lennox-Gastaut syndrome, a form of
childhood-onset epilepsy that causes frequent seizures and developmental problems. TOPAMET® tablets 15mg
are also used for the prevention of migraines in adults who have regular migraines (3 or more per month).
Topiramate is a sulfamate-substituted monosaccharide. TOPAMET® (topiramate) Tablets are available as 15 mg round tablets.


What Topiramate tablets are and what they are used for

Topiramate belongs to a group of medicines called antiepileptic medicines. It is used
alone to treat seizures in adults and children over age 6
with other medicines to treat seizures in adults and children over age 2
to prevent migraine headaches in adults.


 Before you take

Do not take Topiramate tablets and tell your doctor
if you are allergic (hypersensitive) to topiramate or any of the other ingredients of Topiramate tablets (see section 6).
for migraine prevention do not take if you are pregnant or you are able to become pregnant but you are not using effective contraception (see ‘Pregnancy and breastfeeding’ for further information).
Check with your doctor or pharmacist before taking Topiramate tablets if you
have kidney problems, especially kidney stones, or are having kidney dialysis
have a history of blood and body fluid abnormality (metabolic acidosis)
have liver problems
have eye problems especially glaucoma
have a growth problem
are on a high fat diet.

Other warnings
It is important that you do not stop taking your medicine without first consulting your doctor.
You should also talk to your doctor before taking any other medicine containing topiramate that is given to you as an alternative to Topiramate tablets.
You may experience significant and continuing weight loss while taking Topiramate tablets. Therefore your weight should be checked regularly when using this medicine. If you are losing too much weight or if a child using this medicine is not gaining enough weight, you should consult your doctor.
A small number of people being treated with anti-epileptic medicines such as Topiramate tablets have had thoughts of harming or killing themselves. If at any time you have these thoughts, contact your doctor at once.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, vitamins and herbal medicines. Topiramate and certain other medicines can affect each other. Sometimes the dose of some of your other medicines or Topiramate tablets will have to be adjusted.
Especially, tell your doctor or pharmacist if you are taking:
other medicines that impair or decrease your thinking, concentration, or muscle coordination (e.g. central nervous system depressant medicines such as muscle relaxants and sedatives).
birth control pills as Topiramate may make these pills less effective. If your menstrual bleeding changes, you have breakthrough bleeding or spotting, tell your doctor.
other antiepileptic medicines
risperidone, lithium, amitriptyline, venlafaxine (for depression)
hydrochlorothiazide, propranolol, diltiazem (for angina and high blood pressure)
metformin, pioglitazone, glyburide (anti diabetic medicines)
flunarazine.

Taking Topiramate tablets with food and drink
You can take Topiramate tablets with or without food.
To prevent kidney stones whilst being treated with Topiramate tablets, drink plenty of fluids during the day.
You should avoid drinking alcohol when taking Topiramate tablets.
Pregnancy and breast-feeding
Talk to your doctor before using Topiramate tablets if you are pregnant, trying to become pregnant or are breast-feeding. Your doctor will decide if you can take Topiramate tablets. As with other antiepilepsy medicines, there is a risk of harm to the unborn child if Topiramate tablets are used during pregnancy. Make sure you are very clear about the risks and the benefits of using Topiramate tablets for epilepsy during pregnancy.

You should not take Topiramate for migraine prevention if you are pregnant or are able to become pregnant and are not using effective contraception.
Mothers who breastfeed while taking Topiramate tablets must tell the doctor as soon as possible if the baby experiences anything unusual.
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Dizziness, tiredness and vision problems may occur whilst taking Topiramate tablets. Do not drive or use any tools or machines without talking to your doctor first.
Important information about one of the ingredients of Topiramate tablets
Topiramate 50mg, 100mg and 200mg tablets contain lecithin (soya oil). If you are allergic to peanuts or soya, do not use this medicinal product.


How to take

Always take Topiramate tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
Your doctor will usually start you on a low dose and slowly increase your dose until the best dose is found.
Swallow whole. Do not chew. Take with or without food. To prevent kidney stones while taking Topiramate tablets, drink plenty of fluids during the day.
If you take Topiramate tablets only for epilepsy
Adults – starting dose of 25mg at night. The dose will be slowly increased to a maintenance dose, usually 100-200mg a day in 2 divided doses. Maximum dose of 500mg a day in 2 divided doses.
Children over 6 years of age – starting dose of 0.5-1mg per kg of body weight at night increasing slowly to a maintenance dose, usually 100mg a day.
If you take Topiramate tablets with another epilepsy medicine
Adults – starting dose of 25-50mg at night. The dose will be slowly increased to a maintenance dose, usually 200-400mg a day in 2 divided doses.
Children over 2 years of age – starting dose of 1-3mg per kg of body weight at night increasing slowly to a maintenance dose, usually 5-9mg per kg of body weight a day in 2 divided doses.
Prevention of migraines
Adults – starting dose of 25mg at night. The dose will be slowly increased to a maintenance dose of 100mg a day in 2 divided doses.
Children – Not recommended for use in children.
If you take more Topiramate tablets than you should
See a doctor right away. Take the medicine pack with you.
Signs and symptoms of overdose may include; feeling sleepy or tired, abnormal body movements, problems standing and walking, feeling dizzy due to low blood pressure, abnormal heart beats or fits, double vision, changes in thinking and alertness, loss of consciousness, speech problems, changes in mood or behaviour (including anger or depression), stomach pain.
Overdose can happen if you are taking other medicines together with Topiramate tablets.
If you forget to take Topiramate tablets
If you forget to take a dose, take it as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue as usual. If you miss two or more doses, contact your doctor. Do not take a double dose (two doses at the same time) to make up for a forgotten dose.
If you stop taking Topiramate tablets
Do not stop taking this medicine even if you feel better unless your doctor tells you to as your symptoms may return. If your doctor decides to stop this medication, your dose may be decreased gradually over a few days.
If you have any further questions on the use of this product, ask your doctor or pharmacist.


 Possible side effects

Like all medicines, Topiramate tablets can cause side effects, although not everybody gets them.
Contact your doctor at once if you have the following side effects:
signs of an allergic reaction such as difficulty breathing, swelling of the face, lips, trunk and limbs, hives, skin rash and redness or severe skin reactions such as flushing, blisters and ulcers.
severe skin reactions, including Stevens-Johnson syndrome, a life threatening skin condition in which the upper layer of the skin separates from the lower, and erythma multiforme, a condition of raised red spots that can blister.
Toxic epidermal necrolysis which is a more severe form of Stevens-Johnson syndrome.
Maculopathy is a disease of the macula, the small spot in the retina where vision is keenest. You should call your doctor if you notice a change or decrease in your vision.
problems with the eyes including signs of raised pressure in the eye (glaucoma) such as blurred or decreased vision, eye pain and redness of the eyes.
Tell your doctor if you notice any of the following side effects or notice any other effects not listed:
Very common (affects more than 1 user in 10):
weight loss, diarrhoea, feeling sick
tingling in the arms and legs
drowsiness or sleepiness, tiredness, dizziness
stuffy, runny nose and sore throat
depression
Common (affects 1 to 10 users in 100):
changes in mood or behaviour including anger, nervousness, sadness
changes in thinking and alertness including confusion, problems with concentration, memory or slowness in thinking
weight gain, decrease or loss of appetite
being sick, constipation, stomach pain, indigestion
dry mouth, altered sense of taste, tingling or numbness of the mouth
kidney stones causing sudden pain in the abdomen, frequent or painful urination
reduced number of red blood cells. You may notice excessive tiredness, paleness of the skin.
slurred speech, clumsiness or problems with walking, involuntary shaking in the arms, hands or legs
reduced sense of touch or sensation
ringing sound in the ears, ear pain
shortness of breath, nose bleeds
skin rash and/or itchy skin, hair loss
joint pain, muscle spasms, muscle twitching or muscle weakness, loss of strength
chest pain
fever, general feeling of being unwell
Uncommon (affects 1 to 10 users in 1,000):
wind, heartburn, fullness or bloating, increased appetite
increased thirst and drinking abnormally large amounts of fluid
crystals in the urine, leakage of urine and/or stools, urgent desire to urinate
changes in the numbers and types of blood cells. You may notice increased bruising, nosebleeds, sore throats, infections, breathlessness on exertion.
increased acid levels in the blood, low potassium levels in the blood (causing muscle twitching or weaknesses, abnormal heart beat)
irregular heartbeat or slowness of the heart beat
swollen glands in the neck armpit or groin
increase in seizures
problems with or decreased verbal communication, problems with learning or handwriting
drooling, decreased or loss of sweating
restlessness or increased mental and physical activity, hallucinations, loss of consciousness, fainting, disturbed or poor quality sleep
reduced or altered sense of smell
feeling of movement under the skin, skin discolouration, pins and needles
decreased or loss of hearing, hoarseness of the voice
inflammation of the pancreas, causing severe abdominal pain
loss of sensitivity to touch in the mouth, painful or burning sensations in the mouth, breath odour, bleeding gums
swelling of the joints, stiffness, slow or reduced movements
low blood pressure or drop in blood pressure that occurs when you stand up
hot flushing, flu like illness, cold extremities (e.g. hands and feet)
disturbances in sexual function (erectile dysfunction, loss of libido)
Rare (affects 1 to 10 users in 10,000):
excessive skin sensitivity, odour
renal tubular acidosis
raynaud’s syndrome. A disorder affecting the blood vessels, in the fingers, toes, ears and causing pain and cold sensitivity
abdominal build up of calcium salts in the tissues
increase in liver enzymes seen in tests
yellowing of the skin or eyes, or tiredness, pain in the abdomen, joints or muscles (hepatitis, hepatic failure)
Unknown (cannot be estimated from the available data):
cough

Tell your doctor if you notice any of the above side effects or notice any other effects not listed.


 How to store

Keep out of the reach and sight of children.
Do not store above 25°C.
Do not use after the expiry date which is stated on the label. The expiry date refers to the last day of that month.
Topiramate tablets which are supplied in bottles must be used within 60 days of opening. There is a space provided on the bottle for you to write the date that you opened them.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


 Further information

What Topiramate tablets contains:
The active substance (the ingredient that makes the tablet work) is topiramate. Each tablet contains either 25mg, 50mg, 100mg or 200mg of the active substance.
The other ingredients are mannitol, starch (pregelatinised), cellulose (microcrystalline), croscarmellose sodium, silica (colloidal anhydrous), magnesium stearate, polyvinyl alcohol, titanium dioxide, macrogols (macrogol 3350), talc.
The following ingredients are also in the:
50mg and 100mg tablets - lecithin (Soya) (E322) and iron oxide yellow (E172).
200mg tablets - lecithin (Soya) (E322) and iron oxide red (E172).
What Topiramate tablets look like and contents of the pack
25mg tablets are round, biconvex, white tablets.
50mg tablets are round, biconvex, light yellow tablets.
100mg tablets are round, biconvex, yellow tablets.
200mg tablets are oval, biconvex, salmon-coloured tablets.


Pack size of 10,30's ,60 tablets.

Marketing Authorisation Holder
TAJ Group PTC ehf
Reykjavikurvegur 43-12
2123 Hafnarfjordur
Iceland
Manufacturer
TAJTEFA hf
Reykjavikurvegur 78
IS-321 Hafnarfjordur
Iceland

AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

GLUCORAGE ® (Metformin Hcl Tablets & combinations) First-line agent to treat type 2 diabetes mellitus ,Antihyperglycemic drugs used to treat type 2 diabetes.

GLUCORAGE ® (Metformin Hcl Tablets & combinations)








First-line agent to treat type 2 diabetes mellitus ,Antihyperglycemic drugs used to treat type 2 diabetes.

GLUCORAGE ® (Metformin Hcl Tablets & combinations) is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment
of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by
safety concerns although at least one study has been conducted which showed no concerns for children prenatally exposed to Metformin up to 2 years of age.
It is also used in the treatment of polycystic ovary syndrome, and has been investigated for other diseases where insulin resistance may be an
important factor. Metformin works by suppressing glucose production from three-carbon molecules
(like propionic acid, a by product of dietary fibre fermentation in the large intestine and pyruvate, a by product of glucose breakdown in the muscles) by the liver.

GLUCORAGE ® (Metformin Hcl Tablets & combinations) is primarily used for type 2 diabetes, but is increasingly being used
in polycystic ovary syndrome (PCOS),[14] and in prediabetes.

Type 2 diabetes
The American Diabetes Association recommends metformin as a first-line agent to treat type 2 diabetes mellitus.

COMBINATIONS AVAILABLE FOR: Type 2 Diabetes

Linagliptin/metformin hydrochloride) Tablets
2.5 mg linagliptin/500 mg metformin HCl

Metformin hydrochloride and Glibenclamide

Vildagliptin/Metformin hydrochloride

Glyburide and Metformin hydrochloride
tablets, USP

Metformin Hydrochloride and Voglibose Tablets

METFORMIN HYDROCHLORIDE EXTENDED-RELEASE

Benfotiamine and metformin HCl tablets.

GLUCORAGE ® is a registered trademark of Taj Pharma A/S.
US Patent No. 56,663,21

Manufactured for: TAJ PHARMA LIMITED A/S
DK-6755 Bagsvaerd, Denmark
For information contact: Taj Pharma Inc. 332 College RoadWest
Princeton, New Jersey 08540
 or www.tajpharma.com
© 2008–2014 TAJ GROUP., INDIA
432WSSWE 332-1 April 2012

Livoral ® (Adementionine) 400mg Tablets, For the treatment of alcoholic liver disease (ALD) due to its detoxication, antioxidant, chloretic, cytoprotective ...

Livoral ® (Adementionine) 400mg Tablets, For the treatment of alcoholic liver disease (ALD) due to its detoxication, antioxidant, chloretic, cytoprotective ...








Livoral® (Adementionine) 400mg Tablets is a form of the amino acid methionine.
It also is called S-adenosylmethionine, or SAMe.

*Gastroenterology & Hepatology /*Gastroesophageal reflux disease (GERD)

Additional but inconclusive research suggests that it also may be useful for treating symptoms of:
depression /cirrhosis of the liver /chronic viral hepatitis / jaundice in pregnancy /Gilbert’s syndrome
fibromyalgia/ nerve problems related to AIDS/ cholestasis (blocked bile flow from the liver to the gall bladder).

What Is Livoral® (Adementionine) 400mg Tablets?
Ademetionine is a form of the amino acid methionine. It also is called S-adenosylmethionine, or SAMe.
Typically, a human body makes all the ademetionine it needs for good health. However, low levels of methionine, folate,
or vitamin B12 can cause a drop in ademetionine levels. Since this chemical doesn’t exist in foods, a synthetic version is
sometimes used to normalize levels in the body.

Livoral® (Adementionine) 400mg Tablets is sold as a dietary supplement in the United States. In Europe, it is used as a prescription drug.

What Does Livoral® (Adementionine) 400mg Tablets Do?
SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals,
such as serotonin, melatonin, and dopamine.

Ademetionine - Livoral belongs to a group of hepatoprotectors with antidepressive activity. Heptral exerts bile-expelling action, possesses detoxification, regeneration, anti oxidative, anti fibrosis and neuroprotective properties. Ademetionine fills the deficiency of Ademetionine and stimulates its production in organism as well. Ademetionine takes part in transmethylation reactions, increases the amount of glutamine in the liver, cysteine and turin in plasma. Ademiteonine also normalizes metabolic processes in the liver.
Indications:

Non-calculous chronic cholecystitis
Cholangitis
Intrahepatic cholestasis
Liver damage caused by toxic substances, alcohol, viruses, drugs(antibiotics, antiviral preparation, tricyclic antidepressant and others)
Hepatic steatosis
Chronic hepatitis
Liver cirrhosis
encephalopathy associated with liver failure
Depression
Abstinent syndrome(including alcoholic).

Indications: hepatic cholestasis, hepatic encephalopathy, cirrhosis, depression, alcohol withdrawal syndrome

Depression and osteoarthritis and liver disorders.

Brand Name(s): Livoral  (by Taj Pharmaceuticals Limited)
Usage : Anti Depressants
Active Ingredient: Adementionine 400mg
Supplied Form: Tablet

Livoral (active ingredient: Ademetionine) treats many liver ailments such as liver damage, hepatic steatosis, chronic hepatitis, cirrhosis of the liver and also treats certain forms of depression. The active ingredient belongs to a group of drugs called hepatoprotectors which exhibit antidepressive activity. It has been shown to work by detoxifying and regenerating cells within the body.

Ademetionine is sold under other brand names such as Livoral, Heptral, Donamet, Samyr and Tunik.

Copyright © 2014 Taj Pharma India Limited. All Rights Reserved.
Please read the Legal Notice for further details or visit: www.tajpharma.com

SENTRANE ® (Acitretin) 25 mg Capsules, Type of medicine known as a retinoid.

SENTRANE ® (Acitretin) 25 mg Capsules, Type of medicine known as a retinoid.




SENTRANE® (Acitretin) 25 mg Capsules is a second-generation retinoid.
It is taken orally, and is typically used for psoriasis.

* A retinoid (similar to vitamin A)

Used for : Severe psoriasis and some other skin conditions.

SENTRANE® (Acitretin) 25 mg Capsules is used to treat severe skin conditions, such as psoriasis, where the surface of the skin has become thick and scaly.
Normally, as new skin cells are produced, older ones are lost. With psoriasis, the skin cells in the outer layer of your skin multiply faster than normal and the
old skin cells build up on the surface of your skin, causing red, scaly patches.
SENTRANE® (Acitretin) is a retinoid, which means that it is related to vitamin A. Our bodies use vitamin A to maintain a healthy skin.
SENTRANE® (Acitretin) helps to control psoriasis by making your skin grow more normally.

It is a metabolite of etretinate, which was used prior to the introduction of SENTRANE® (Acitretin) 25 mg Capsules. Etretinate was discontinued because it had a narrow therapeutic index as well as a
long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because SENTRANE® (Acitretin) 25 mg Capsules can be reverse
metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years  after discontinuing acitretin.
Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.
SENTRANE® (Acitretin) 25 mg Capsules is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only
very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte
differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. SENTRANE® (Acitretin) 25 mg Capsules is readily absorbed and widely distributed after oral administration.
A therapeutic effect occurs after 2 to 4 weeks or longer.
Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
The product information provided in this site is intended only for residents of the United States.

The products discussed herein may have different product labeling in different countries.

TAJ, Inc, is a wholly owned subsidiary of Taj Pharmaceuticals, Inc.
SENTRANE ® is a registered trademark of Taj Pharmaceuticals International, Inc.

www.tajpharma.com

Use of this site signifies your agreement to the Terms of Use. Privacy Policy.
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SEPAMET® XR (sitagliptin and metformin HCl extended-release) tablets, Antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.

SEPAMET® XR (sitagliptin and metformin HCl extended-release) tablets









SEPAMET® XR (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the
management of type 2 diabetes: sitagliptin and metformin hydrochloride.

Sepamet XR is a prescription medicine that contains 2 prescription diabetes medicines, sitagliptin (Sepamet ®) and extended-release metformin. Sepamet XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

Sepamet XR targets 3 key factors to lower blood sugar:
Helps your pancreas make more insulin
Helps your body more effectively use the insulin that it makes
Helps decrease excess sugar that your liver makes
Sepamet XR:
Helps control blood sugar throughout the day, including after meals
Is not likely to cause weight gain and low blood sugar (hypoglycemia) by itself

Important Information
SEPAMET® XR is indicated, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus when
treatment with both sitagliptin and metformin extended-release is appropriate.
SEPAMET® XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.

SEPAMET® XR has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis
are at increased risk of developing pancreatitis while taking SEPAMET® XR.

SEPAMET® XR is contraindicated in patients with renal impairment (serum creatinine levels greater than or equal to 1.5 mg/dL for men and
greater than or equal to 1.4 mg/dL for women or abnormal creatinine clearance); hypersensitivity to metformin hydrochloride; acute or chronic
metabolic acidosis, including diabetic ketoacidosis; or history of a serious hypersensitivity reaction to SEPAMET® XR or sitagliptin,
such as anaphylaxis or angioedema.

About Sepamet XR and Sepamet

Sepamet tablets contain 2 prescription medicines: sitagliptin Sepamet ®) and metformin. Once-daily prescription Sepamet XR tablets contain sitagliptin (the medicine inSepamet ®) and extended-release metformin.

Sepamet or Sepamet XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. Your doctor will determine whether Sepamet or Sepamet XR is right for you.

Sepamet or Sepamet XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking Sepamet or Sepamet XR.

This site has information about type 2 diabetes and how Sepamet XR and Sepamet work to help lower blood sugar. You will also find tools to track your progress and other resources to help you ask the questions that are important to you at your next doctor appointment.

Also, check out Steps to Diabetes Goals, a program that provides information on type 2 diabetes, including tips and tools that you may find useful.

Talk to your doctor to see whether Sepamet® XR (sitagliptin and metformin HCl extended-release) or Sepamet® (sitagliptin and metformin HCl) could be right for you.

Selected Risk Information About Sepamet and Sepamet XR
Metformin, one of the ingredients in Sepamet and Sepamet XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Stop taking Sepamet or Sepamet XR and call your doctor right away if you get any of the following symptoms of lactic acidosis: you feel very weak or tired; have unusual (not normal) muscle pain; have trouble breathing; have unusual on Screen Detectsleepiness or sleep longer than usual; have sudden stomach or intestinal problems with nausea and vomiting or diarrhea; feel cold, especially in your arms and legs; feel dizzy or lightheaded; or have a slow or irregular heartbeat.
You have a higher chance of getting lactic acidosis if you have kidney problems, liver problems, or congestive heart failure that requires treatment with medicines; if you drink alcohol very often, drink a lot of alcohol in a short period of time, or get dehydrated (lose large amounts of body fluids); if you have certain x-ray tests with dyes or contrast agents that are injected into your body; or if you have surgery, a heart attack, severe infection, or stroke.
Pancreatitis is another serious side effect that can happen in people taking Sepamet or Sepamet XR. Pancreatitis may be severe and lead to death. Before you start taking Sepamet or Sepamet XR, tell your doctor if you've ever had pancreatitis. Stop taking Sepamet or Sepamet XR and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.
Do not take Sepamet or Sepamet XR if you are allergic to any of the ingredients in Sepamet or Sepamet XR. Allergic reactions, which may be serious, including rash; hives; and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have an allergic reaction, stop taking Sepamet or Sepamet XR and call your doctor right away.
Do not take Sepamet or Sepamet XR if your kidneys are not working properly. Your doctor will do blood tests before and during your treatment to see how well your kidneys are working.
Tell your doctor if you are going to get an injection of dye or contrast agent for an x-ray procedure; Sepamet or Sepamet XR will need to be stopped for a short time.
If you take Sepamet or Sepamet XR with another medicine that can cause low blood sugar (hypoglycemia), such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heart beat, sweating, and feeling jittery.
Kidney problems, sometimes requiring dialysis, have been reported.
Common side effects when taking Sepamet or Sepamet XR include stuffy or runny nose and sore throat, upper respiratory tract infection, diarrhea, nausea and vomiting, gas, upset stomach, indigestion, weakness, headache, and low blood sugar (hypoglycemia) when used in combination with certain medications, such as a sulfonylurea or insulin.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Supplier
Sepamet XR is manufactured & supplied by:

Taj Pahrmaceuticals Limited.,
P O Box 33242
Newmarket
Auckland
NEW ZEALAND

www.tajpharma.com


CP-TPL-999898-UUBH(4438A)

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