SENTRANE ® (Acitretin) 25 mg Capsules, Type of medicine known as a retinoid.
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SENTRANE® (Acitretin) 25 mg Capsules is a second-generation retinoid.
It is taken orally, and is typically used for psoriasis.
* A retinoid (similar to vitamin A)
Used for : Severe psoriasis and some other skin conditions.
SENTRANE® (Acitretin) 25 mg Capsules is used to treat severe skin conditions, such as psoriasis, where the surface of the skin has become thick and scaly.
Normally, as new skin cells are produced, older ones are lost. With psoriasis, the skin cells in the outer layer of your skin multiply faster than normal and the
old skin cells build up on the surface of your skin, causing red, scaly patches.
SENTRANE® (Acitretin) is a retinoid, which means that it is related to vitamin A. Our bodies use vitamin A to maintain a healthy skin.
SENTRANE® (Acitretin) helps to control psoriasis by making your skin grow more normally.
It is a metabolite of etretinate, which was used prior to the introduction of SENTRANE® (Acitretin) 25 mg Capsules. Etretinate was discontinued because it had a narrow therapeutic index as well as a
long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because SENTRANE® (Acitretin) 25 mg Capsules can be reverse
metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin.
Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.
SENTRANE® (Acitretin) 25 mg Capsules is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only
very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte
differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. SENTRANE® (Acitretin) 25 mg Capsules is readily absorbed and widely distributed after oral administration.
A therapeutic effect occurs after 2 to 4 weeks or longer.
Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
The product information provided in this site is intended only for residents of the United States.
The products discussed herein may have different product labeling in different countries.
TAJ, Inc, is a wholly owned subsidiary of Taj Pharmaceuticals, Inc.
SENTRANE ® is a registered trademark of Taj Pharmaceuticals International, Inc.
www.tajpharma.com
Use of this site signifies your agreement to the Terms of Use. Privacy Policy.
©2014 Taj Pharmaceuticals, Inc. All rights reserved. FREWE-998223QA
332 Colonnade Center Drive, Raleigh, NC 27612 USA
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SENTRANE® (Acitretin) 25 mg Capsules is a second-generation retinoid.
It is taken orally, and is typically used for psoriasis.
* A retinoid (similar to vitamin A)
Used for : Severe psoriasis and some other skin conditions.
SENTRANE® (Acitretin) 25 mg Capsules is used to treat severe skin conditions, such as psoriasis, where the surface of the skin has become thick and scaly.
Normally, as new skin cells are produced, older ones are lost. With psoriasis, the skin cells in the outer layer of your skin multiply faster than normal and the
old skin cells build up on the surface of your skin, causing red, scaly patches.
SENTRANE® (Acitretin) is a retinoid, which means that it is related to vitamin A. Our bodies use vitamin A to maintain a healthy skin.
SENTRANE® (Acitretin) helps to control psoriasis by making your skin grow more normally.
It is a metabolite of etretinate, which was used prior to the introduction of SENTRANE® (Acitretin) 25 mg Capsules. Etretinate was discontinued because it had a narrow therapeutic index as well as a
long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because SENTRANE® (Acitretin) 25 mg Capsules can be reverse
metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin.
Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.
SENTRANE® (Acitretin) 25 mg Capsules is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only
very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte
differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. SENTRANE® (Acitretin) 25 mg Capsules is readily absorbed and widely distributed after oral administration.
A therapeutic effect occurs after 2 to 4 weeks or longer.
Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
The product information provided in this site is intended only for residents of the United States.
The products discussed herein may have different product labeling in different countries.
TAJ, Inc, is a wholly owned subsidiary of Taj Pharmaceuticals, Inc.
SENTRANE ® is a registered trademark of Taj Pharmaceuticals International, Inc.
www.tajpharma.com
Use of this site signifies your agreement to the Terms of Use. Privacy Policy.
©2014 Taj Pharmaceuticals, Inc. All rights reserved. FREWE-998223QA
332 Colonnade Center Drive, Raleigh, NC 27612 USA
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